Selank
WELL RESEARCHEDAnxiolytic peptide | Synthetic tuftsin analog
By the INFOPEPTIDOS editorial team · content based on scientific literature.
Updated: August 2026.
Key points
- What it is: anxiolytic peptide derived from tuftsin.
- Main use: anxiety, stress and mood.
- Typical dose: 250–500 mcg per day, intranasal route.
- Key result: anxiolytic effect without sedation or dependence, used in Russia.
- Common effects: mild; occasional nasal irritation.
- Comparison: vs Semax: Selank is more calming; Semax more cognitive.
- Status: not FDA-approved.
Technical data: Molecular formula C33H57N11O9 · Molecular weight 751.9 g/mol. Source: PubChem.
Overview
What is Selank?
Selank is a synthetic heptapeptide analog of tuftsin, developed in Russia and studied for its anxiolytic (anti-anxiety) and nootropic effects, without the sedation or dependence of classic anxiolytics. It works by modulating the GABA system and increasing BDNF levels. It is not FDA-approved.
Key benefits
Anxiety reduction without sedation, improved mood and mental clarity, a nootropic effect and immune modulation, with a good safety profile.
Mechanism of action
It modulates the GABAergic system and serotonin and dopamine levels, stabilizes enkephalins (inhibiting their breakdown) and increases BDNF. Its intranasal administration helps it reach the brain quickly.
Quick start guide
Dosing protocol
| Phase | Dose | Route | Frequency |
|---|---|---|---|
| Standard | 250–500 mcg | Intranasal | 1–2 times/day (in cycles) |
The specific dose must be assessed by a healthcare professional.
🧮 Calculate your exact syringe dose →Semax vs Selank
| Semax | Selank | |
|---|---|---|
| Main effect | Cognition and focus | Anxiolysis and calm |
| Mechanism | BDNF and dopamine | Tuftsin, GABA/serotonin |
| Route | Intranasal | Intranasal |
| FDA status | Not approved | Not approved |
⚠️ Who should NOT use it
- Pregnancy or breastfeeding.
- Always under the supervision of a healthcare professional.
What to expect
- Day 1-3: possible feeling of calm without sedation.
- Week 1: less anxiety and better mood.
- Week 2-3: greater mental clarity and stress resistance.
- Week 4: consolidated benefits.
- Side effects: generally mild; possible nasal irritation.
Side effects & safety
- Generally well tolerated; the most common side effect is mild nasal irritation.
- It does not cause sedation or dependence like classic anxiolytics, but use it in moderation.
- Long-term safety data outside Russia are limited: use with supervision.
- Not recommended during pregnancy or breastfeeding.
- Consult your doctor if you take anxiolytics or antidepressants.
- Allergic reaction: rash, itching or swelling.
- Increased anxiety, marked mood changes or sleep disturbances.
- Intense or persistent nasal irritation.
- If you are pregnant, breastfeeding or planning a pregnancy.
Frequently asked questions
What is Selank?
Selank is a synthetic heptapeptide analog of tuftsin, developed in Russia and studied for its anxiolytic and nootropic effects.
What is Selank researched for?
It is studied for anxiety, mood, mental clarity and immune system modulation.
How does Selank work?
It modulates the GABA system and serotonin and dopamine levels, stabilizes enkephalins and increases BDNF.
How long does Selank take to work?
Anxiolytic effects are described in 30-60 minutes and full benefits in 1-2 weeks.
What is the usual Selank dose?
Most commonly 250-500 µg per day. The schedule should be assessed by a professional.
How is Selank administered?
Intranasally, as a spray in each nostril.
How is Selank stored?
Refrigerated and protected from light. See the storage guide.
What are the side effects of Selank?
It is described as well tolerated; the most common is mild nasal irritation. It does not cause sedation or dependence like classic anxiolytics.
Which peptides is Selank combined with?
The most cited combination is Selank with Semax, aimed at anxiety and cognitive function.
Is Selank approved?
It is not FDA-approved; in Russia it is used in the context of anxiety.
What is the difference between Selank and Semax?
Selank is more anxiolytic (anxiety), while Semax is more nootropic (cognition).
Research areas
- Anxiety reduction
- Mood
- Mental clarity
- Immune modulation
- Stress resistance
Related peptides
- Semax — Nootropic peptide; classic combination with Selank.
- Epitalon — Pineal tetrapeptide related to sleep and longevity.
- MOTS-c — Mitochondrial peptide associated with energy and metabolism.
Related articles
Related topics
- Selank for anxiety
- Selank and mood
- Selank dose
- Selank vs Semax
- Selank nootropic
- Selank and stress
Summary
What it is: Anxiolytic heptapeptide analog of tuftsin.
How it is researched: Intranasal, 250-500 µg per day.
Key features: Reduces anxiety without sedation; modulates GABA. Not FDA-approved.
Related peptides: Semax, Epitalon and MOTS-c.
References
- Panikratova YR et al. (2020). Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. PubMed · DOI
- Medvedev VE et al. (2014). [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. PubMed
- Kasian A et al. (2017). Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. PubMed · DOI
- Filatova E et al. (2017). GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front Pharmacol. PubMed · DOI
Studies compiled from PubMed for informational purposes; many are preclinical or research-stage and do not constitute medical advice.