TB-500

WELL RESEARCHED

Ac-LKKTETQ | Synthetic fragment (17-23) of thymosin beta-4

Typical dose
2-5 mg
2-3 times a week
Route
Injectable
Subcutaneous or intramuscular
Cycle
6-8 weeks
Typical duration
Storage
2-6 °C
Refrigerated

Overview

What is TB-500?

TB-500 is a synthetic 7-amino-acid fragment (Ac-LKKTETQ) corresponding to the active actin-binding region (positions 17-23) of thymosin beta-4. Originally developed for veterinary use in horses, this fragment retains tissue-repair and anti-inflammatory properties while being more stable than the full peptide. It is banned by WADA for its performance-enhancing effects.

Key benefits

Superior systemic tissue repair, accelerated healing of muscles, tendons, ligaments and organs. Enhanced cell migration and angiogenesis for comprehensive regenerative effects.

Mechanism of action

Injectable TB-500 distributes systemically to repair tissues throughout the body. It acts as the main actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation and activating stem cell differentiation for accelerated healing.

Quick start guide

Typical dose
2-3 mg
How often
2-3 times a week
Where to inject
Belly, thigh, shoulder (subcutaneous) or large muscles (intramuscular)
Injection timing
Flexible, before or after meals
Effects timeline
2-4 weeks for tissue effects; 1-2 weeks for inflammation
Storage
Fridge at 2-6 °C, use within a few weeks
Cycle length
6-12 weeks
Break between
4-6 weeks

What to expect

Side effects & safety

Frequently asked questions

What is TB-500?

TB-500 is a synthetic 7-amino-acid fragment (Ac-LKKTETQ) corresponding to the active actin-binding region of thymosin beta-4.

What is TB-500 researched for?

It is studied for systemic tissue repair, muscle and tendon recovery, and inflammation reduction.

How does TB-500 work?

It acts as an actin-sequestering protein, promoting cell migration, angiogenesis and tissue regeneration throughout the body.

How long does TB-500 take to work?

In the literature, effects on inflammation are described within 1-2 weeks and tissue-repair effects around 2-4 weeks.

What is the usual TB-500 dose?

Published protocols use 2-5 mg per week, split into 2-3 applications. The schedule should be assessed by a professional.

How is TB-500 administered?

Subcutaneously or intramuscularly; being systemic, it does not need to be injected at the injury site.

How is TB-500 stored?

As a powder, refrigerated; reconstituted, in the fridge (2-6 °C), using it within a few weeks. More details in the storage guide.

What are the possible side effects of TB-500?

It is usually described as well tolerated, with possible mild reactions at the injection site. Long-term safety data in humans are lacking.

Which peptides is TB-500 combined with?

The most cited combination is TB-500 with BPC-157 for tissue and injury recovery.

What is the difference between TB-500 and BPC-157?

TB-500 has a more systemic action (whole body), while BPC-157 is associated with a more localized action.

Is TB-500 approved?

It is not approved for human use and is banned by WADA in competitive sport.

Research areas

Related peptides

Related articles

Related topics

Summary

What it is: Synthetic 7-amino-acid fragment of thymosin beta-4.

How it is researched: Subcutaneous or intramuscular, 2-5 mg per week in 2-3 applications.

Key features: Systemic action; associated with cell migration and angiogenesis. Not approved for human use and banned by WADA.

Related peptides: BPC-157, CJC-1295 and Ipamorelin.