Kisspeptin-10
INVESTIGATIONALReproductive axis activator | Libido and fertility
By the INFOPEPTIDOS editorial team · content based on scientific literature.
Updated: August 2026.
Key points
- What it is: active fragment of the kisspeptin peptide, master regulator of the reproductive axis.
- Main use: libido, fertility and reproductive hormonal activation.
- Typical dose: 50–100 mcg, subcutaneous, per the research protocol.
- Key result: stimulates GnRH neurons, setting the entire hormonal axis in motion.
- Common effects: well tolerated; mild injection-site reaction.
- Comparison: acts upstream of GnRH; further 'upstream' than gonadorelin.
- Status: not FDA-approved (research compound).
Technical data: Molecular formula C63H83N17O14 · Molecular weight 1302.4 g/mol. Source: PubChem.
Overview
What is kisspeptin-10?
Kisspeptin-10 is the active fragment of kisspeptin, a peptide that acts as the 'master switch' of the reproductive axis. It sits at the top of the hormonal cascade: it stimulates the neurons that release GnRH and, with it, the entire signal toward the pituitary and gonads. It is researched for its effects on libido and fertility.
Key benefits
It physiologically activates the reproductive axis, with possible effects on sexual desire and as a fertility tool. Unlike more direct stimuli, it respects natural regulation by acting at the highest point of the cascade.
Mechanism of action
It binds KISS1R receptors on hypothalamic GnRH neurons and activates them. This triggers the release of GnRH and, in cascade, LH and FSH, and finally sex hormones. It is the initial step of the reproductive axis.
Quick start guide
Dosing protocol
| Phase | Dose | Route | Duration |
|---|---|---|---|
| Standard | 50–100 mcg | Subcutaneous | In cycles |
Doses and regimens come from research studies and vary widely. The regimen must be set by a healthcare professional.
Reconstitution: units in the syringe
Example with a 5 mg vial + 2 ml of bacteriostatic water → a 2.5 mg/ml solution. On a U-100 insulin syringe (100 units = 1 ml):
| Dose | Volume | Units (U-100) |
|---|---|---|
| 50 mcg | 0.02 ml | 2 U |
| 100 mcg | 0.04 ml | 4 U |
Is your vial or water different? Calculate the exact units below.
🧮 Calculate your exact syringe dose →Kisspeptin-10 vs Gonadorelin
| Kisspeptin-10 | Gonadorelin | |
|---|---|---|
| Level of action | Hypothalamus (upstream) | Pituitary |
| Effect | Stimulates natural GnRH | Releases LH/FSH directly |
| Typical use | Libido and fertility | TRT support and fertility |
| Regulation | Very physiological | Direct |
⚠️ Who should NOT use it
- People with undiagnosed hormonal disorders — consult first.
- Pregnancy or breastfeeding.
- Hormone-dependent tumors — assess with the doctor.
- Always under the supervision of a healthcare professional.
What to expect
- Minutes-hours: rapid increase in LH and testosterone.
- Week 1-2: possible effect on libido.
- Week 2-4: support for the reproductive axis.
- In cycles: adjusted to the goal (libido or fertility).
- Side effects: minimal; mild injection reaction.
- Most effective for: libido and reproductive axis activation.
Side effects & safety
- Very well tolerated in general.
- Mild injection-site reaction.
- Hormonal changes (part of the intended effect).
- Occasional headache or flushing.
- Variable response from person to person.
- Allergic reaction: rash, itching or swelling.
- Severe pelvic or abdominal pain.
- Severe headache or vision changes.
- Any striking, persistent symptom.
- If you are pregnant or planning a pregnancy.
Frequently asked questions
What is kisspeptin-10?
It is the active fragment of kisspeptin, the master regulator of the reproductive axis that activates GnRH neurons.
What is kisspeptin-10 used for?
It is researched for libido, fertility and physiological activation of the reproductive hormonal axis.
How does it differ from gonadorelin?
Kisspeptin acts upstream (in the hypothalamus, on GnRH); gonadorelin acts on the pituitary.
What is the kisspeptin-10 dose?
Around 50-100 mcg subcutaneously, per research protocols. The regimen is set by a professional.
What are the side effects?
It is usually very well tolerated; mild injection reaction and variable response.
Is kisspeptin-10 approved?
No; it is a research compound not approved by the FDA.
Research areas
- Libido
- Fertility
- Reproductive axis
- Hormonal regulation
- Sexual function
Related peptides
- Gonadorelin — GnRH analog that acts on the pituitary.
- PT-141 — Melanocortin agonist for sexual function.
- Oxytocin — The bonding and connection hormone.
Related articles
Related topics
- Kisspeptin and libido
- Kisspeptin-10 dose
- Kisspeptin and fertility
- Kisspeptin vs gonadorelin
- Kisspeptin hormonal axis
- Kisspeptin side effects
Summary
What it is: Active fragment of kisspeptin.
How it is researched: Subcutaneous, 50-100 mcg, in cycles.
Key features: Activates the reproductive axis upstream. Not FDA-approved.
Related peptides: Gonadorelin, PT-141 and Oxytocin.
References
- Li Z et al. (2024). Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nat Commun. PubMed · DOI
- Navarro VM (2020). Metabolic regulation of kisspeptin - the link between energy balance and reproduction. Nat Rev Endocrinol. PubMed · DOI
- Abreu AP et al. (2016). Pubertal development and regulation. Lancet Diabetes Endocrinol. PubMed · DOI
- Radwańska P et al. (2023). Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity. Sci Rep. PubMed · DOI
Studies compiled from PubMed for informational purposes; many are preclinical or research-stage and do not constitute medical advice.