Epitalon

WELL RESEARCHED

Synthetic pineal tetrapeptide | Telomerase activator & anti-aging

Typical dose
100-500 µg
Once a day
Route
Injectable
Subcutaneous: abdomen, thigh or arm
Cycle
10-20 days
Typical duration
Storage
2-8 °C
Refrigerated

Overview

What is Epitalon?

Epitalon (Epithalon, AEDG) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on a natural pineal gland peptide. Developed by Russian scientist Vladimir Khavinson and studied for more than 35 years, it is researched mainly for its ability to activate telomerase, lengthen telomeres and potentially slow cellular aging through several mechanisms, including melatonin regulation and gene expression modulation. IMPORTANT: current Western dosing protocols may be 50-100 times higher than necessary, due to translation errors from the Russian literature.

Key benefits

Telomerase activation to lengthen telomeres, increased melatonin production, improved immune function, possible lifespan extension and systemic anti-aging effects through cellular rejuvenation. CORRECTED DOSING: evidence suggests current Western protocols use doses 50-100 times higher than the original Russian research.

Mechanism of action

It activates the telomerase enzyme at extremely low concentrations to maintain telomere length, stimulates the pineal gland to produce melatonin, modulates gene expression through epigenetic mechanisms and enhances antioxidant enzyme systems.

Quick start guide

Typical dose
200-500 µg per injection
How often
Once a day for 10-20 days
Where to inject
Subcutaneous: abdomen, thigh or arm
Injection timing
Morning injection, preferable to align with natural circadian rhythms
Effects timeline
Sleep: 3-7 days; energy: 1-2 weeks; cellular markers: 1-3 months
Storage
Refrigerate at 2-8 °C, use within 30 days after reconstitution
Cycle length
10-20 days per cycle
Break between
4-6 months between cycles

What to expect

Side effects & safety

Frequently asked questions

What is Epitalon?

Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on a natural pineal gland peptide. It is researched mainly for its ability to activate telomerase.

What is Epitalon researched for?

It is studied for telomerase and telomere activation, melatonin production, sleep, anti-aging and longevity.

How does Epitalon work?

It activates the telomerase enzyme at very low concentrations, stimulates the pineal gland to produce melatonin and modulates gene expression.

How long does Epitalon take to work?

Sleep improvements are described in 3-7 days, energy in 1-2 weeks and changes in cellular markers in 1-3 months.

What is the usual Epitalon dose?

Most commonly 200-500 µg per injection during cycles of 10-20 days. The schedule should be assessed by a professional.

How is Epitalon administered?

Subcutaneously, preferably in the morning to match circadian rhythms.

How is Epitalon stored?

Refrigerated, using it within 30 days after reconstitution. See the storage guide.

What are the side effects of Epitalon?

It is described as well tolerated; some users report vivid dreams due to increased melatonin. It is advisable to avoid it in case of active cancer due to its action on telomerase.

Which peptides is Epitalon combined with?

It is usually paired with GHK-Cu or MOTS-c in the anti-aging context.

Is Epitalon approved?

It is not FDA-approved, although it has extensive clinical experience in Russia.

Does Epitalon help with longevity?

It is its most researched area: its relationship with telomere length and cellular aging is studied.

Research areas

Related peptides

Related articles

Related topics

Summary

What it is: Synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly).

How it is researched: Subcutaneous, 200-500 µg, in cycles of 10-20 days.

Key features: Activates telomerase and melatonin; anti-aging. Not FDA-approved.

Related peptides: GHK-Cu, MOTS-c and Semax.